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Member of suzhou university

Dr. Rui Peng

Date:2019-01-09      Views:499


Rui Peng

Professor


B.S., Nanjing University, Dept. of Biochemistry, 1996

M.S., Nanjing University, Dept. of Biochemistry, 1999

Ph.D., Vanderbilt University (US), Dept. of Biological Sciences, 2005


Tel: 0512-65880947    

Email: rpeng@suda.edu.cn

  

Research Interests: 
Nanobiotechnology, Molecular Cell Biology, RNA Biology.

As a molecular biologist, my recent interests focus on applying molecular, cellular, and nanobiology approaches to understand and control of the nano/bio and bio/bio interfaces for unveiling the biological effects of various nanomaterials and the development of their bio-applications. In particular, we engineered various functionalized nanomaterials and discovered their selective interactions with proteins (immune factors and enzymes, reported by Nanowerk) and cells (bacterial cells and immune cells). We further unveiled the mechanisms underneath, based on which we developed novel applications of such nanomaterials in enzyme engineering, microbial engineering, antibacterial agents, and cancer immunotherapy.

Research Projects:

1. Biological effects and applications of nanomaterials;

2. Nanomaterials/nanocomposites as antibacterial agents;

3. Nano-carriers for cancer immunotherapy;

4. Biosensors for monitoring bio-interactions.


Selected Publications:

  1. Fengyun Shen, Lele Sun*, Lihua Wang, Rui Peng*, Chunhai Fan, and Zhuang Liu*. Framework Nucleic Acid Immune Adjuvant for Transdermal Delivery Based Chemo-immunotherapy for Malignant Melanoma Treatment, Nano Letters, 2022, 22, 4509−4518

  2. Qi Zhuang, Jun Xu, Dashi Deng, Ting Chao, Junyan Li, Rui Zhang, Rui Peng*, Zhuang Liu*. Bacteria-derived membrane vesicles to advance targeted photothermal tumor ablation, Biomaterials, 2021, 268, 120550-120563

  3. Jun Xu, Jia Lv, Qi Zhuang, Zongjin Yang, Zhiqin Cao, Ligeng Xu, Pei Pei, Chenya Wang, Hanfei Wu, Ziliang Dong, Yu Chao, Chao Wang, Kai Yang, Rui Peng*, Yiyun Cheng* and Zhuang Liu*. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy. Nature Nanotechnology, 2020, 15, 1043-1052

  4. Fengyun Shen, Liangzhu Feng*, Yujie Zhu, Danlei Tao, Jun Xu, Rui Peng*, Zhuang Liu*. Oxaliplatin-/NLG919 prodrugs-constructed liposomes for effective chemoimmunotherapy of colorectal cancer. Biomaterials, 2020, 255, 120190

  5. Chenya Wang§, Yuanpeng Xiao§, Wenwen Zhu, Jiacheng Chu, Jun Xu, He Zhao, Fengyun Shen, Rui Peng*, and Zhuang Liu*. Photosensitizer-Modified MnO2 Nanoparticles to Enhance Photodynamic Treatment of Abscesses and Boost Immune Protection for Treated Mice. Small, 2020, 2000589

  6. Jun Xu, Hui Wang, Ligeng Xu, Yu Chao, Chenya Wang, Xiao Han, Ziliang Dong, Hong Chang, Rui Peng*, Yiyun Cheng*, Zhuang Liu*. Nanovaccine based on a protein-delivering dendrimer for effective antigen cross-presentation and cancer immunotherapy, Biomaterials, 2019, 207, 1-9

  7. Rong Yang, Jun Xu, Ligeng Xu*, Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui Peng*, and Zhuang Liu*. Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination, ACS Nano, 2018, 12, 6, 5121-5129

  8. Yonghui Wang, Jun Xu, Ligeng Xu, Xiaofang Tan, Liangzhu Feng, Yinchan Luo, Jian Liu, Zhuang Liu, Rui Peng*. Functionalized graphene oxide triggers cell cycle checkpoint control through both the ATM and the ATR signaling pathways,Carbon, 2018, 129, 495-503

  9. Jun Xu, Ligeng Xu,* Chenya Wang, Rong Yang, Qi Zhuang, Xiao Han, Ziliang Dong, Wenwen Zhu, Rui Peng*, and Zhuang Liu*. Near-Infrared-Triggered photodynamic therapy with multi-tasking upconversion nanoparticles in combination with checkpoint blockade for immunotherapy of colorectal cancer. ACS Nano, 2017, 11, 4463–4474

  10. Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng & Zhuang Liu*. Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nat. Commun., 2017, 8, 902

  11. Qian Chen,‡ Ligeng Xu,‡ Chao Liang, Chao Wang, Rui Peng & Zhuang Liu*. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat. Commun., 2016, 7, 13193

  12. Ligeng Xu, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu* and Rui Peng*, Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity. Nanoscale, 2016, 8, 3785 (2016 Hot Articles in Nanoscale)

  13. Yinchan Luo, Xinxing Yang, Xiaofang Tan, Ligeng Xu*, Zhuang Liu, Jie Xiao, Rui Peng*, Functionalized graphene oxide in microbial engineering: An effective stimulator for bacterial growth, Carbon, 2016, 13, 172-180

  14. Ligeng Xu, Jian Xiang, Rui Peng*, Zhuang Liu.* Recent advances in the development of nanomaterials for DC-based immunotherapy.Sci. Bull., 2016, 61, 514-523

  15. Jian Xiang, Ligeng Xu*, Hua Gong, Wenwen Zhu, Chao Wang, Jun Xu, Liangzhu Feng, Liang Cheng, Rui Peng*, and Zhuang Liu*, Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy. ACS Nano, 2015, 9, 6401–6411

  16. Kai Yao, Pengli Tan, Yinchan Luo, Liangzhu Feng, Ligeng Xu, Zhuang Liu, Youyong Li*, and Rui Peng*, Graphene Oxide Selectively Enhances Thermostability of Trypsin. ACS Appl. Mater. Interfaces, 2015, 7, 12270–12277

  17. Hua Gong, Jian Xiang, Ligeng Xu,* Xuejiao Song, Ziliang Dong, Rui Peng* and Zhuang Liu*, Stimulation of immune systems by conjugated polymers and their potential as an alternative vaccine adjuvant. Nanoscale, 2015,7, 19282-19292

  18. Fei Tian, Guangcun Chen, Peiwei Yi, Jichao Zhang, Aiguo Li, Jing Zhang, Lirong Zheng, Zongwu Deng, Qin Shi*, Rui Peng*, and Qiangbin Wang*. Fates of Fe3O4 and Fe3O4@SiO2 Nanoparticles in Human Mesenchymal Stem Cells Assessed by Synchroton Radiation-Based Techniques. Biomaterials, 2014, 35, 6412-6421

  19. Chao Wang, Ligeng Xu, Chao Liang, Jian Xiang, Rui Peng, and Zhuang Liu*. Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti-CTLA-4 Therapy to Inhibit Cancer Metastasis. Adv. Mater., 2014, 26, 8154–8162

  20. Tengfei Tian, Xiaoze Shi, Liang Cheng, Yinchan Luo, Ziliang Dong, Hua Gong, Ligeng Xu, Zengtao Zhong, Rui Peng*, and Zhuang Liu*. Graphene-Based Nanocomposite As an Effective, Multifunctional, and Recyclable Antibacterial Agent. ACS Appl. Mater. Interfaces, 2014, 6, 8542–8548

  21. Liming Qu, Jinhai Xu, Xiaofang Tan, Zhuang Liu, Ligeng Xu*, and Rui Peng*. Dual-Aptamer Modification Generates a Unique Interface for Highly Sensitive and Specific Electrochemical Detection of Tumor Cells. ACS Appl. Mater. Interfaces, 2014, 6, 7309-7315

  22. Shuai Fang, Chao Wang, Jian Xiang, Liang Cheng, Xuejiao Song, Ligeng Xu, Rui Peng*, and Zhuang Liu*. Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells. Nano Res., 2014, 7, 1327-1336

  23. Yanfeng Zhou, Xiangxu Jiang, Jia Tang, Yuanyuan Su, Fei Peng, Yimei Lu, Rui Peng*, and Yao He*. A Silicon-Based Antibacterial Material of Robust and High Antibacterial Activity. J. Mater. Chem. B, 2014, 2, 691-697

  24. Ligeng Xu, Liang Cheng, Chao Wang, Rui Peng*, and Zhuang Liu*. Conjugated polymers for photothermal therapy of cancer. Polym. Chem., 2014, 5, 1573-1580 (2014's most accessed Polymer Chemistry Top10 articles; Invited Review)

  25. Hua Gong, Rui Peng*, Zhuang Liu*, Carbon nanotubes for biomedical imaging:  The recent advances. Adv. Drug Deliver. Rev. 2013, 65, 1951-63 (Invited Review)

  26. Kai Yang, Yingjie Li, Xiaofang Tan, Rui Peng* and Zhuang Liu*, Behavior and Toxicity of Graphene and Its Functionalized Derivatives in Biological Systems. Small, 2013, 9: 1492-1503

  27. Liangzhu Feng, Xianzhu Yang, Xiaozhe Shi, Xiaofang Tan, Rui Peng, Jun Wang*, Zhuang Liu*, Polyethylene Glycol and Polyethylenimine Dual-Functionalized Nano-Graphene Oxide for Photothermally Enhanced Gene Delivery. Small, 2013, 9, 1989-1997

  28. Jia Tang, Qian Chen, Ligeng Xu, Shuai Zhang, Liangzhu Feng, Liang Cheng, Huan Xu, Zhuang Liu* and Rui Peng*, Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms. ACS Appl. Mater. Interfaces, 2013, 5, 3867–3874

  29. Xiaofang Tan, Liangzhu Feng, Jing Zhang, Kai Yang, Shuai Zhang, Zhuang Liu* and Rui Peng*. Functionalization of Graphene Oxide Generates a Unique Interface for Selective Serum Protein Interactions. ACS Appl. Mater. Interfaces, 2013, 5, 1370–1377

  30. Jing Zhang, Liangzhu Feng, Xiaofang Tan, Xiaozhe Shi, Ligeng Xu, Zhuang Liu* and Rui Peng*, Dual-Polymer-Functionalized Nanoscale Graphene Oxide as a Highly Effective Gene Transfection Agent for Insect Cells with Cell-Type-Dependent Cellular Uptake Mechanisms, Part. & Part. Syst. Char., 2013, 30, 794–803.

  31. Liling Jin, Kai Yang, Kai Yao, Shuai Zhang, Huiquan Tao, Shuit-Tong Lee, Zhuang Liu* and Rui Peng*. Functionalized Graphene Oxide in Enzyme Engineering: A Selective Modulator for Enzyme Activity and Thermostability. ACS Nano, 2012, 6, 4864–4875  (High lighted byNanowerk)

  


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